Tag Archive | "nocturia"

Solifenacen May Improve Sleep-Related Quality of Life for Overactive Bladder and Nocturia Patients


Adults who have an overactive bladder and nocturia might benefit from solifenacin, which may improve quality of sleep and sleep-related quality of life by decreasing the number of overnight trips to the bathroom and increasing the amount of urination per trip.  Solifenacin is a urinary antispasmodic approved by the US Food and Drug Administration (FDA) for use in adults in 2005.  It works by relaxing bladder muscles to prevent urgent, frequent, or uncontrolled urination.

These new findings come from a subgroup exploratory analysis of 962 Japanese men and women, 20 years or older with overactive bladder and nocturia, who participated in a randomized, controlled 12-week trial study evaluating solifenacen (5 and 10 milligrams) against a placebo.  Only participants who urinated at least once overnight were included in the analysis.  The participants recorded their results in a bladder diary.  While the decrease in nocturia was statistically significant for those given 10 milligrams of solifenacen, the results were not statistically significant for those given 5 milligrams.

Both the 5mg and 10mg dose significantly increased the amount of urination per trip to the bathroom by 30 and 41 milliliters, respectively.  With both doses, the amount of undisturbed sleep time increased by an average of 59 and 60 minutes, respectively, compared to 33 minutes with the placebo.  The study showed most significant improvements in sleep-related quality of life.  Because of the exploratory nature of this study, the authors of the Journal of Urology report caution that the results need to be interpreted with caution.  The analysis was supported by Astellas Pharma Inc.

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Sleep Problems Associated with Incontinence


According to the results of a new study, sleep problems are associated with urologic conditions such as incontinence, lower urinary tract symptoms (LUTS) and nocturia – the need to get up during the night to urinate.

For five years, researchers at New England Research Institutes, Inc. in Watertown Massachusetts followed 1,610 men and 2,535 women assessing sleep disturbances and the development of urologic symptoms.

The investigators found that short sleep duration among men and restless sleep in both men and women was strongly associated with the incidence of lower urinary tract symptoms – 8% among men and 13% among women. Incidences of urinary incontinence and nocturia were associated with restless sleep among women but not in men.

The study is scheduled to be presented to the media during a special press conference at the American Urological Association’s (AUA) annual meeting in Washington, D.C. along with another study that examined the relationship between obstructive sleep apnea (OSA) and erectile dysfunction.

In the association’s news release, Dr. Kevin T McVary, AUA spokesman said “We know that proper amounts of sleep and quality of sleep can impact a wide range of health conditions, these data may help us better assess how helping patients modify their sleep patterns may help improve their health and overall quality of life.”

The data and conclusions of these studies should be viewed as preliminary until published in a peer-reviewed journal because these studies were presented during a medical meeting.

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