Tag Archive | "weight loss"

Weight Loss Increases Libido in Obese Men with Type 2 Diabetes

A small Australian clinical study showed that sexual function improved significantly and quickly in obese men with type 2 diabetes after weight loss with reduced-calorie diets.  For 31 men who lost five percent to ten percent of their body weight in eight weeks, erectile function, sexual desire, and urinary symptoms all improved significantly.  According to an article published in the Journal of Sexual Medicine, metabolic parameters, including blood glucose, insulin sensitivity, and lipid profile, also responded favorably to either a low-calorie, meal-replacement diet or a high protein-low carbohydrate diet.

The improvements were maintained during a year of follow-up.  Joan Khoo, MRCP, of Changi General Hospital in Singapore, and Australian co-authors wrote, “Further improvements during weight maintenance, using a high-protein low-fat diet, suggest that both nutrient quality and caloric restriction contribute to these benefits.”  Although the favorable effect of weight loss on sexual function is not new, this study may be the first to demonstrate an impact on sexual desire.

Another important finding was weight loss’ apparently favorable effect on systemic inflammation.  Obesity and type 2 diabetes increase the risk of erectile dysfunction and lower urinary tract symptoms (LUTS), which are associated with each other and with systemic inflammation and endothelial dysfunction.

Rapid weight loss through dieting can improve erectile dysfunction and LUTS. Previous studies also have shown improved endothelial function and reduced inflammation after weight loss, especially for people who lose at least 10 percent of body weight.  Not much data had been collected regarding the influence of macronutrient composition on associations between weight loss, endothelial function, systemic inflammation, sexual function, and LUTS in obese men.

All 31 men involved in the study had type 2 diabetes, a body mass index greater than 30, and a waist circumference of at least 102cm.  They were randomized to two dietary plans.  The first plan was a liquid meal-replacement consumed twice daily and one small, nutritionally balanced meal, providing a total energy of about 900 kcal/day (low-calorie diet).  The second plan was a low-fat, low-carbohydrate diet designed to reduce energy intake by about 600 kcal/day.

The first assessment occurred after eight weeks, and follow-up continued for an additional 44 weeks.  The participants who opted to stay in the study for long-term follow-up consumed the high-protein diet during the follow-up.

Men in the low-calorie diet group had about ten percent reduction in mean body weight and waist circumference at eight weeks, as compared with about five percent among men assigned to the high-protein diet.  Weight loss at eight weeks averaged 9.5kg with the low-calorie diet and 5.4 kg with the high-protein diet, both of which were statistically significant.

In general, inflammatory markers decreased significantly in the high-protein group but not the low-calorie group, but the men assigned to the high-protein diet had higher baseline levels of the markers.  About half of the men remained in the study for the entire 52 weeks. Of those who did, improvements were either maintained or increased.

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No Relationship Found Between Weight Changes and LUTS

Even though obesity has been related to lower urinary tract symptoms (LUTS) in aging men, new findings from researchers at the Mayo Clinic College of Medicine in Rochester, Minnesota suggest that modest weight loss may not prevent the onset or progression of LUTS among these men.  Also, no relationship was found between weight gain and the development or progression of LUTS.

The research team analyzed data from 1,674 white men participating in the Olmstead County Study (OCS) of Urinary Symptoms and Health Status among Men, funded by Merck Research Laboratories, and 168 black men participating in the Flint Men’s Health Study.  Researchers separated the participants into three categories based on differences between their baseline weight and weight during four year of follow-up: no weight loss, less than 5% of baseline weight loss, and more than 5% of baseline weight loss.

Jennifer L. St. Sauver, Ph.D., the lead author of the study, reported at the American Urological Association annual meeting that participants in both studies and in all weight categories experienced no statistically significant change in LUTS.  Her research team found that in the OCS cohort, weight loss was not related to receipt of treatment for benign prostatic hyperplasia.  Dr. St. Sauver concludes that although weight loss can help prevent a number of diseases such as diabetes, modest weight loss may not prevent development of LUTS.  A report of the study will be published in Urology. Data collection for this study was additionally funded by grants from the National Institutes of Health.

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Weight Loss and Urinary Incontinence in Women

A new study from the University of Bergen in Norway suggests that it might not be how much weight a woman gains during pregnancy, but how much she loses afterward that affects her post-childbirth urinary incontinence risk.

Previous research has demonstrated that excess weight, especially abdominal weight, is correlated with a heightened risk of urinary incontinence in women. Additionally, overweight and obese women who lost weight reduced their risk of developing incontinence.

Urinary incontinence is also related to pregnancy, and many women have problems with leakage during pregnancy. Additionally, vaginal delivery is a risk factor for developing urinary incontinence at some point in a woman’s life. Until now, it was not clear whether the amount of weight a woman gains during gestation affects her risk of incontinence before or after childbirth.

The new study discovered only a weak relationship between pregnancy weight gain and the risk of incontinence, and there was no correlation between the amount of weight gained during pregnancy and the chances of incontinence six months after delivery. However, researchers did find that women who shed more pounds after childbirth had a lower risk of incontinence six months after having their baby, and that weight gain post-delivery was linked to an increased risk.

“For decades,” lead researcher Stian Langeland Wesnes explained, “obstetricians have assumed that weight gain during pregnancy to a large degree could explain the peak in urinary incontinence during pregnancy, but scientific proof of the hypothesis has been lacking.”

He and his colleagues speculate that it is possible that the type of weight gain matters. For non-pregnant women, body fat is the main culprit of weight gain. However, during pregnancy, much of the excess weight is due to the fetus, placenta and increased body fluids.

This suggests that there may be something about body fat — possibly alterations in hormone levels — that affects the risk of urinary incontinence. However, Wesnes cautioned that more research is still needed on the subject.  However, according to the researchers, current findings suggest that “weight loss postpartum, together with pelvic floor muscle training, may decrease the prevalence of urinary incontinence in women postpartum.”

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